This study was conducted to investigate the qualitative and quantitative phytochemical content of the crude extracts of Archidium ohioense, Pelekium gratum, and Hyophila involuta with different alcoholic solvents (ethanol, methanol, Seaman's Schnapps, fresh oil-palm wine, and fresh Raffia-palm wine). The mosses were collected from their natural populations on the central campus of the Obafemi Awolowo University, Ile-Ife, Nigeria. The yield of the extracts was weighed for all the solvents, and the qualitative and quantitative evaluations of the extracts were carried out using standard methods. The results of phytochemical analysis of the crude extracts from the mosses showed the presence of saponins, cardiac glycosides, triterpenes, alkaloids, flavonoids, and steroids. The quantitative phytochemical analysis of the crude extracts showed that ethanolic extracts of Hyophila involuta had the highest flavonoid content (288.37±0.10 mg RE/g), and Raffia-palm-wine extracts of Hyophila involuta had the highest saponin content (224.70±0.02 mg/g), while the methanolic extract of Archidium ohioense had the highest cardiac glycosides content (63.71±0.14 mg/g), and the Raffia-palm wine extract of Hyophila involuta had the highest alkaloids content (102.50±0.12 mg/g). Raffia- and oil-palm wines were observed to be the most effective solvents for all the mosses studied, followed by Seaman's Schnapp, while methanol and ethanol were less effective. The study concluded that the extracts of the mosses studied contain pharmacologically active constituents that can be used for therapeutic purposes.